Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gnastm1.2Plag
Name:	GNAS complex locus; targeted mutation 1.2, Antonius Plagge
MGI ID:	MGI:5320901
Gene:	Gnas  Location: Chr2:174126113-174188537 bp, + strand  Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Alliance:	Gnastm1.2Plag page

Germline Transmission:	Earliest citation of germline transmission: J:184320
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-meditated recombination inverted the exon 2SA and lacZ leaving a lox2272 site at the 5' end and loxP site at the 3' end. The allele expresses a fusion product between the XL domain and lacZ. qRT-PCR confirmed a 90% downregulation of transcript expression. (J:184320)

Generation of the Gnastm1.1Plag and Gnastm1.2Plag alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnas Mutation:	53 strains or lines available

Original:	J:184320 Krechowec SO, et al., Postnatal changes in the expression pattern of the imprinted signalling protein XLalphas underlie the changing phenotype of deficient mice. PLoS One. 2012;7(1):e29753
All:	1 reference(s)