Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Scribtm1.2Phum Name: scribbled planar cell polarity; targeted mutation 1.2, Patrick O Humbert MGI ID: MGI:5299427 Gene: Scrib  Location: Chr15:75919011-75941633 bp, - strand  Genetic Position: Chr15, 35.29 cM Alliance: Scribtm1.2Phum page

Craniorachischisis in Scribtm1.2Phum/Scribtm1.2Phum mice Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:178461
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exons 4 through 13 from Scribtm1.1Phum. Western blot analysis confirmed the absence of protein expression in embryos. (J:178461)

Generation of the Scribtm1.1Phum and Scribtm1.2Phum alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:	53 strains or lines available

Original:	J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
All:	5 reference(s)