Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nox4tm1.1Ams
Name:	NADPH oxidase 4; targeted mutation 1.1, Ajay M Shah
MGI ID:	MGI:4838549
Gene:	Nox4  Location: Chr7:86895304-87047918 bp, + strand  Genetic Position: Chr7, 48.96 cM
Alliance:	Nox4tm1.1Ams page

Germline Transmission:	Earliest citation of germline transmission: J:165541
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exons 1 and 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the hearts and kidneys of homozygous mice. (J:165541)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nox4 Mutation:	70 strains or lines available

Original:	J:165541 Zhang M, et al., NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6
All:	17 reference(s)