Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cux2tm1.1Nieto
Name:	cut-like homeobox 2; targeted mutation 1.1, Marta Nieto
MGI ID:	MGI:4429541
Gene:	Cux2  Location: Chr5:121996025-122188522 bp, - strand  Genetic Position: Chr5, 62.02 cM
Alliance:	Cux2tm1.1Nieto page

Germline Transmission:	Earliest citation of germline transmission: J:156578
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 22 and 23 were floxed to create a premature stop at the C-teminus in the presence of cre recombinase. A Neo cassette and a 3rd loxP site were inserted within intron 23. Exons 22, 23 and the neo cassette were removed by cre-mediated recombination. Absence of protein in brain was confirmed by western blot and immunohistochemistry. (J:156578)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cux2 Mutation:	43 strains or lines available

Original:	J:156578 Cubelos B, et al., Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone. Cereb Cortex. 2008 Aug;18(8):1758-70
All:	5 reference(s)