Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ikzf2tm1Kast
Name:	IKAROS family zinc finger 2; targeted mutation 1, Philippe Kastner
MGI ID:	MGI:4355173
Synonyms:	Helios-
Gene:	Ikzf2  Location: Chr1:69570373-69726404 bp, - strand  Genetic Position: Chr1, 34.9 cM
Alliance:	Ikzf2tm1Kast page

Germline Transmission:	Earliest citation of germline transmission: J:151553
Parent Cell Line:	P1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin cassette replaced the segment of exon 7 that lies between SalI and XbaI restriction sites. This mutation deleted sequences that encode the C-terminal zinc finger domains. The locus produced truncated mRNA as determined by RT-PCR. No protein was detected in immunoblot analysis of homozygote thymus extracts using an antibody specific to the N-terminal of the protein. (J:151553)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf2 Mutation:	38 strains or lines available

Original:	J:151553 Cai Q, et al., Helios deficiency has minimal impact on T cell development and function. J Immunol. 2009 Aug 15;183(4):2303-11
All:	8 reference(s)