Phenotypes associated with this allele

• Allele Symbol: Ikzf2^tm1Kast
• Allele Name: targeted mutation 1, Philippe Kastner
• Allele ID: MGI:4355173
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikzf2^tm1Kast/Ikzf2^tm1Kast	B6.129S2-Ikzf2^tm1Kast	MGI:4355174
hm2	Ikzf2^tm1Kast/Ikzf2^tm1Kast	involves: 129S2/SvPas * C57BL/6	MGI:4355175

Genotype
MGI:4355174

hm1

• Allelic Composition: Ikzf2^tm1Kast/Ikzf2^tm1Kast
• Genetic Background: B6.129S2-Ikzf2^tm1Kast

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:151553 )

• all mice die before weaning due to unknown causes

Genotype
MGI:4355175

hm2

• Allelic Composition: Ikzf2^tm1Kast/Ikzf2^tm1Kast
• Genetic Background: involves: 129S2/SvPas * C57BL/6

mortality/aging

preweaning lethality, incomplete penetrance ( J:151553 )

• most mice die of unknown causes before weaning age

• mice that survive weaning have a normal life span

• Background Sensitivity: further backcrossing onto the C57BL/6 strain increases percentage of mice that die

growth/size/body

decreased body weight ( J:151553 )

• mice are smaller than controls at 7-8 weeks of age

• as mice age, the weight of male mice normalizes while females continue to weigh less than controls

vision/eye

abnormal eyelid development ( J:151553 )

• mice have abnormal growth of eyelids

narrow eye opening ( J:151553 )

• mice exhibit smaller eye-openings