Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Elavl1tm1.2Dkon
Name:	ELAV like RNA binding protein 1; targeted mutation 1.2, Dimitris L Kontoyiannis
MGI ID:	MGI:3847912
Synonyms:	HuR-
Gene:	Elavl1  Location: Chr8:4335382-4375413 bp, - strand  Genetic Position: Chr8, 2.0 cM
Alliance:	Elavl1tm1.2Dkon page

Germline Transmission:	Earliest citation of germline transmission: J:149149
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre mediated recombination of the floxed Elavl1tm1Dkon allele results in removal of the ATG-containing second exon and the neo cassette. Gene inactivation was confirmed by a lack of protein in E11.5 extracts as determined by immunoblot analysis. (J:149149)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elavl1 Mutation:	43 strains or lines available

Original:	J:149149 Katsanou V, et al., The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol. 2009 May;29(10):2762-76
All:	2 reference(s)