Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptpn4tm1.1Oers
Name:	protein tyrosine phosphatase, non-receptor type 4; targeted mutation 1.1, Nicolai S C van Oers
MGI ID:	MGI:3809671
Gene:	Ptpn4  Location: Chr1:119580197-119765281 bp, - strand  Genetic Position: Chr1, 52.39 cM, cytoband E2
Alliance:	Ptpn4tm1.1Oers page

Germline Transmission:	Earliest citation of germline transmission: J:138871
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: In vivo Cre mediated recombination of Ptpn4tm1Oers removed exons 21 - 24. RT-PCR confirmed the absence of the full length transcript but detected low levels of a truncated transcript in the thymus, spleen and testes of homozygous mice. (J:138871)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn4 Mutation:	50 strains or lines available

Original:	J:138871 Young JA, et al., The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions. Mol Immunol. 2008 Aug;45(14):3756-66
All:	1 reference(s)