Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Del(10Prtn3-Elane)1Deje
Name:	Deletion, Chr 10, Dieter E Jenne 1
MGI ID:	MGI:3803339
Synonyms:	Del1Deje, Ela2/Prtn3tm1Deje, Elane/Prtn3tm1Deje, Prtn3-Ela2-
Gene:	Del(10Prtn3-Elane)1Deje  Location: unknown  Genetic Position: Chr10, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:137674
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion, Intragenic deletion   Del(10Prtn3-Elane)1Deje involves 2 genes/genome features (Prtn3, Elane) View all   Mutation details: Exons 2 through 5 of Prtn3 and exons 1 through 3 of Elane were replaced with a floxed neo cassette. The neo cassette was removed by transient expression of cre in ES cells. The absence of transcript from either gene was confirmed by RT-PCR on bone marrow extracts. (J:137674)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(10Prtn3-Elane)1Deje Mutation:	0 strains or lines available

Original:	J:137674 Kessenbrock K, et al., Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest. 2008 Jul;118(7):2438-47
All:	8 reference(s)