Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcrgtm1.1Dhr
Name:	T cell receptor gamma chain; targeted mutation 1.1, David Raulet
MGI ID:	MGI:3785563
Synonyms:	Tcrgdelta43
Gene:	Tcrg  Location: Chr13:19362212-19540646 bp, + strand  Genetic Position: Chr13, cytoband A2-A3

Germline Transmission:	Earliest citation of germline transmission: J:133974
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Tcrgtm1.1Dhr involves 3 genes/genome features (Tcrg, Trgv4, Trgv3) View all   Mutation details: The variable regions 3 and 4 were replaced with a floxed neo cassette and a variable region 4 and 2 with a 5' loxP site. Transient cre expression in ES cells was used to remove the neo cassette and the inserted variable region 4 and 2 leaving only the endogenous variable region 2. (J:133974)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcrg Mutation:	1 strain or line available

Original:	J:133974 Xiong N, et al., Gene placement and competition control T cell receptor gamma variable region gene rearrangement. J Exp Med. 2008 Apr 14;205(4):929-38
All:	1 reference(s)