Phenotypes associated with this allele

• Allele Symbol: Tcrg^tm1.1Dhr
• Allele Name: targeted mutation 1.1, David Raulet
• Allele ID: MGI:3785563
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcrg^tm1.1Dhr/Tcrg^tm1.1Dhr	involves: 129	MGI:3795460

Genotype
MGI:3795460

hm1

• Allelic Composition: Tcrg^tm1.1Dhr/Tcrg^tm1.1Dhr
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell receptor gamma chain V-J recombination ( J:133974 )

• there is a five fold increase in Vgamma2 gene rearrangements in E14 fetal thymoyctes compared to wild-type embryos

• Vgamma2 rearrangements are still elevated in E15 thymocytes though to a lesser extent

• Vgamma5 rearrangements are increased three fold compared to E14 thymocytes in wild-type embryos

• germline transcripts are found at the same level as in wild-type embyros in E14 thymocytes

hematopoietic system

abnormal T cell receptor gamma chain V-J recombination ( J:133974 )

• there is a five fold increase in Vgamma2 gene rearrangements in E14 fetal thymoyctes compared to wild-type embryos

• Vgamma2 rearrangements are still elevated in E15 thymocytes though to a lesser extent

• Vgamma5 rearrangements are increased three fold compared to E14 thymocytes in wild-type embryos

• germline transcripts are found at the same level as in wild-type embyros in E14 thymocytes