Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkar2btm2Gsm
Name:	protein kinase, cAMP dependent regulatory, type II beta; targeted mutation 2, G Stanley McKnight
MGI ID:	MGI:3773428
Synonyms:	RIIbeta -, RIIbetaneolox, RIIbeta-neolox
Gene:	Prkar2b  Location: Chr12:32008475-32111295 bp, - strand  Genetic Position: Chr12, 13.74 cM, cytoband B1
Alliance:	Prkar2btm2Gsm page

Germline Transmission:	Earliest citation of germline transmission: J:131039
Parent Cell Line:	REK3 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A floxed neomycin cassette was inserted in the 5 prime untranslated region of the gene. Homozygous mice show no expression of the gene and are phenotypically identical to homozygote Prkar2btm1Gsm mice. (J:131039)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkar2b Mutation:	27 strains or lines available

Original:	J:131039 Czyzyk TA, et al., Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):276-81
All:	4 reference(s)