Slc4a3tm1Ges
Targeted Allele Detail
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Symbol: |
Slc4a3tm1Ges |
Name: |
solute carrier family 4 (anion exchanger), member 3; targeted mutation 1, Gary E Shull |
MGI ID: |
MGI:3770133 |
Synonyms: |
AE3- |
Gene: |
Slc4a3 Location: Chr1:75522688-75536075 bp, + strand Genetic Position: Chr1, 39.16 cM, cytoband C3
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Alliance: |
Slc4a3tm1Ges page
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Retinal abnormalities in the Slc4a3tm1Ges/Slc4a3tm1Ges mouse
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:129363
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacing most of exon 6, intron 6, the cardiac-specific first exon and promoter, and exon 7 with a neomycin resistance gene. Expression of both the cardiac specific- short isoform and the long isoform of the gene were eliminated in homozygote mice as determined by western blots of retinal extracts.
(J:129363, J:143125)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slc4a3 Mutation: |
42 strains or lines available
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Original: |
J:129363 Alvarez BV, et al., Blindness caused by deficiency in AE3 chloride/bicarbonate exchanger. PLoS One. 2007;2(9):e839 |
All: |
6 reference(s) |
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