Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Catsper3tm1Wyan
Name:	cation channel, sperm associated 3; targeted mutation 1, Wei Yan
MGI ID:	MGI:3720684
Synonyms:	Catsper3-
Gene:	Catsper3  Location: Chr13:55932381-55956811 bp, + strand  Genetic Position: Chr13, 30.06 cM, cytoband B2
Alliance:	Catsper3tm1Wyan page

Germline Transmission:	Earliest citation of germline transmission: J:124054
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 were replaced by a pgk-HPRT cassette in reverse orientation. These exons encode amino acids 152-257, which contain the pore forming region located between the fifth and sixth transmembrane domains of the gene. Northern blot confirmed that the transcript was truncated. (J:124054)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Catsper3 Mutation:	28 strains or lines available

Original:	J:124054 Jin J, et al., Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse. Biol Reprod. 2007 Jul;77(1):37-44
All:	1 reference(s)