Hs6st1tm1Kkm
Targeted Allele Detail
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Symbol: |
Hs6st1tm1Kkm |
Name: |
heparan sulfate 6-O-sulfotransferase 1; targeted mutation 1, Koji Kimata |
MGI ID: |
MGI:3715259 |
Gene: |
Hs6st1 Location: Chr1:36107481-36145527 bp, + strand Genetic Position: Chr1, 15.15 cM, cytoband B
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Alliance: |
Hs6st1tm1Kkm page
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Hs6st1tm1Kkm/Hs6st1tm1Kkm mice exhibit growth retardation and abnormal eye, phalanges, and tarsus morphology
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:122656
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 0.7kb fragment encoding the critical 3'-phosphoadenosine 5'-phosphosulfate binding site was replaced with a neo cassette. The absence of transcript was confirmed by northen blot.
(J:122656)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hs6st1 Mutation: |
26 strains or lines available
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Original: |
J:122656 Habuchi H, et al., Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88 |
All: |
3 reference(s) |
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