Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrp8tm5Her
Name:	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 5, Joachim Herz
MGI ID:	MGI:3698275
Synonyms:	Apoer2 Stop, Apoer2[Stop]
Gene:	Lrp8  Location: Chr4:107659337-107734037 bp, + strand  Genetic Position: Chr4, 50.18 cM, cytoband C7
Alliance:	Lrp8tm5Her page

Germline Transmission:	Earliest citation of germline transmission: J:117956
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A premature stop codon was inserted into the locus on a 434 cDNA encoding the intracellular domain, 5 amino acids downstream of the NFDNPVY sequence. As a result, part of exon 18 and all of exons 19 and 20, were removed. (J:117956)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp8 Mutation:	41 strains or lines available

Original:	J:117956 Beffert U, et al., ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol. 2006 Dec 19;16(24):2446-52
All:	3 reference(s)