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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp8tm5Her
targeted mutation 5, Joachim Herz
MGI:3698275
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp8tm5Her/Lrp8tm5Her Not Specified MGI:3699091


Genotype
MGI:3699091
hm1
Allelic
Composition		 Lrp8tm5Her/Lrp8tm5Her
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp8tm5Her mutation (0 available); any Lrp8 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:117956 )
• corticospinal neuron (CSN) numbers are reduced ~84%
neuron degeneration ( J:117956 )
• lipofuscin autofluorescence is prominent in the neocortex, entorhinal cortex, basal nucleus of Meynert and hippocampus, indicative of degenerative processes

cellular
abnormal neuronal migration ( J:117956 )
• corticospinal neuron (CSN) numbers are reduced ~84%




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory