Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Timp4tm1Vuo Name: tissue inhibitor of metalloproteinase 4; targeted mutation 1, Eero Vuorio MGI ID: MGI:3663251 Gene: Timp4  Location: Chr6:115221405-115229166 bp, - strand  Genetic Position: Chr6, 53.29 cM Alliance: Timp4tm1Vuo page

Cardiac rupture, decreased collagen synthesis, and disruption of collagen network in Timp4tm1Vuo/Timp4tm1Vuo hearts after myocardial infarction Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:112210
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 through 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis on heart extracts. (J:165901)

Generation of the Timp4tm1Vuo allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timp4 Mutation:	10 strains or lines available

Original:	J:112210 English JL, et al., Individual Timp deficiencies differentially impact pro-MMP-2 activation. J Biol Chem. 2006 Apr 14;281(15):10337-46
All:	4 reference(s)