Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Inhbetm1Zuk
Name:	inhibin beta-E; targeted mutation 1, Martin M Matzuk
MGI ID:	MGI:3653272
Synonyms:	actbetaEm1, Inhbctm2Zuk
Gene:	Inhbe  Location: Chr10:127185271-127187717 bp, - strand  Genetic Position: Chr10, 74.5 cM
Alliance:	Inhbetm1Zuk page

Germline Transmission:	Earliest citation of germline transmission: J:110815
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.7 kb fragment including the entire coding region was replaced with a floxed PGK-neo cassette. This line was created with ES cells that were also heterozygous for Inhbctm1Zuk. This insertion is in cis and was used to create the double mutation. (J:110815)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Inhbe Mutation:	12 strains or lines available

Original:	J:110815 Lau AL, et al., Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration. Mol Cell Biol. 2000 Aug;20(16):6127-37
All:	2 reference(s)