Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Polr2atm2Cdn
Name:	polymerase (RNA) II (DNA directed) polypeptide A; targeted mutation 2, J L Corden
MGI ID:	MGI:3641215
Synonyms:	Rpo2-1spe
Gene:	Polr2a  Location: Chr11:69624823-69649459 bp, - strand  Genetic Position: Chr11, 42.86 cM, cytoband B1-C
Alliance:	Polr2atm2Cdn page

Germline Transmission:	Earliest citation of germline transmission: J:53757
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene was inserted outside the transcribed region of the locus and a 13 repeat deletion inserted into the C-terminus. Western blot analysis indicated a smaller protein was present in mutants than in wild-types. (J:53757)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polr2a Mutation:	92 strains or lines available

Original:	J:53757 Litingtung Y, et al., Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II. Mol Gen Genet. 1999 Feb;261(1):100-5
All:	1 reference(s)