All Phenotypes Polr2a<tm2Cdn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Polr2a^tm2Cdn
targeted mutation 2, J L Corden
MGI:3641215

Summary

2 genotypes

Allelic Composition	Polr2a^tm2Cdn/Polr2a^tm2Cdn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr2a^tm2Cdn mutation (0 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• about 30% die in the first few weeks of life

• survivors are those with milder growth retardation

growth/size/body

decreased body weight ( J:53757 )

• surviving adults weigh about 20% less than wild-type mice

postnatal growth retardation ( J:53757 )

• growth retardation becomes more pronounced after birth

decreased fetal size ( J:53757 )

• reduced body weight at E17.5 - E18.5

• growth retardation first apparent in utero

Allelic Composition	Polr2a^tm2Cdn/Polr2a⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr2a^tm2Cdn mutation (0 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal size ( J:53757 )

• reduced body weight at E17.5 - E18.5 compared to wild-type mice, but mice are heavier than homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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