Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Maml1tm1Lizw
Name:	mastermind like transcriptional coactivator 1; targeted mutation 1, Lizi Wu
MGI ID:	MGI:3621180
Synonyms:	Maml1-
Gene:	Maml1  Location: Chr11:50146461-50183138 bp, - strand  Genetic Position: Chr11, 30.42 cM
Alliance:	Maml1tm1Lizw page

Germline Transmission:	Earliest citation of germline transmission: J:106711
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced the first exon and the 5' promoter region. Northern and Western blot confirmed the loss of transcript and protein expression, respectively. (J:106711)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Maml1 Mutation:	26 strains or lines available

Original:	J:106711 Shen H, et al., The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev. 2006 Mar 15;20(6):675-88
All:	2 reference(s)