Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Siglec1tm1Croc
Name:	sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 1, Paul R Crocker
MGI ID:	MGI:3617694
Synonyms:	Sn-
Gene:	Siglec1  Location: Chr2:130911140-130928685 bp, - strand  Genetic Position: Chr2, 63.26 cM, cytoband F-H1
Alliance:	Siglec1tm1Croc page

Germline Transmission:	Earliest citation of germline transmission: J:105546
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a neomycin resistance cassette into exon 3, which encodes the second immunoglobulin-like domain. Quantitative real-time PCR demonstrated that mRNA in mutant spleen is produced at low levels. (J:105546)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Siglec1 Mutation:	82 strains or lines available

Original:	J:105546 Oetke C, et al., Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol. 2006 Feb;26(4):1549-57
All:	17 reference(s)