Phenotypes associated with this allele

• Allele Symbol: Siglec1^tm1Croc
• Allele Name: targeted mutation 1, Paul R Crocker
• Allele ID: MGI:3617694
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglec1^tm1Croc/Siglec1^tm1Croc	B6.129-Siglec1^tm1Croc	MGI:3618247

Genotype
MGI:3618247

hm1

• Allelic Composition: Siglec1^tm1Croc/Siglec1^tm1Croc
• Genetic Background: B6.129-Siglec1^tm1Croc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage phagocytosis ( J:189854 )

• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells

abnormal B cell number ( J:105546 )

• decrease in B220+ cells in spleen and lymph nodes, however no change in maturation status of B cells or in the percentages of B cells in the blood, peritoneal cavity lavages, or the bone marrow

decreased follicular B cell number ( J:105546 )

• spleen exhibits a decrease in follicular B cells

increased marginal zone B cell number ( J:105546 )

• spleen exhibits an increase in the numbers of marginal zone B cells

abnormal T cell subpopulation ratio ( J:105546 )

• decrease in the CD4/CD8 T cell ratio in spleen and mesenteric lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:105546 )

• small increase in CD8+ T cells in spleen, however CD4+ T cells remain unchanged and see no differences in the percentages of T cells in the blood, peritoneal cavity lavages, or the bone marrow

decreased IgM level ( J:105546 )

• 50% or more reduction in IgM levels, however no differences in IgG levels

decreased circulating interleukin-6 level ( J:189854 )

• in mice exposed to sialylated C. jejuni

decreased circulating tumor necrosis factor level ( J:189854 )

• in mice exposed to sialylated C. jejuni

decreased interleukin-10 secretion ( J:189854 )

• in bone marrow-derived macrophage exposed to sialylated and/or opsinized C. jejuni

• however, secretion in response to exposure to heat-killed Salmonella is normal

decreased interleukin-12 secretion ( J:189854 )

• in bone marrow-derived macrophage exposed to sialylated or sialylated and opsinized C. jejuni

• however, secretion in response to exposure to heat-killed Salmonella is normal

decreased interleukin-6 secretion ( J:189854 )

• in bone marrow-derived macrophage exposed to sialylated C. jejuni

• in bone marrow-derived macrophage exposed to sialylated or sialylated and opsinized C. jejuni

• however, secretion in response to exposure to heat-killed Salmonella is normal

decreased tumor necrosis factor secretion ( J:189854 )

• in bone marrow-derived macrophage exposed to sialylated C. jejuni

• in bone marrow-derived macrophage exposed to sialylated or sialylated and opsinized C. jejuni

• however, secretion in response to exposure to heat-killed Salmonella is normal

increased susceptibility to bacterial infection ( J:189854 )

• bone marrow-derived macrophage exposed to sialylated C. jejuni exhibit reduced phagocytosis and production of TNF-alpha and IL6 compared with wild-type cells

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:189854 )

• in mice exposed to sialylated C. jejuni

decreased circulating tumor necrosis factor level ( J:189854 )

• in mice exposed to sialylated C. jejuni

hematopoietic system

impaired macrophage phagocytosis ( J:189854 )

• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells

abnormal B cell number ( J:105546 )

• decrease in B220+ cells in spleen and lymph nodes, however no change in maturation status of B cells or in the percentages of B cells in the blood, peritoneal cavity lavages, or the bone marrow

decreased follicular B cell number ( J:105546 )

• spleen exhibits a decrease in follicular B cells

increased marginal zone B cell number ( J:105546 )

• spleen exhibits an increase in the numbers of marginal zone B cells

abnormal T cell subpopulation ratio ( J:105546 )

• decrease in the CD4/CD8 T cell ratio in spleen and mesenteric lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:105546 )

• small increase in CD8+ T cells in spleen, however CD4+ T cells remain unchanged and see no differences in the percentages of T cells in the blood, peritoneal cavity lavages, or the bone marrow

decreased IgM level ( J:105546 )

• 50% or more reduction in IgM levels, however no differences in IgG levels

cellular

impaired macrophage phagocytosis ( J:189854 )

• bone marrow-derived macrophage exhibit reduced uptake of sialylated C. jejuni compared with wild-type cells