Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Biktm1Ast
Name:	BCL2-interacting killer; targeted mutation 1, Andreas Strasser
MGI ID:	MGI:3612275
Synonyms:	bik-
Gene:	Bik  Location: Chr15:83411063-83428835 bp, + strand  Genetic Position: Chr15, 39.4 cM
Alliance:	Biktm1Ast page

Germline Transmission:	Earliest citation of germline transmission: J:104487
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A beta-gal reporter gene was fused in frame with the endogenous ATG and a loxP-flanked neo cassette. The first and second coding exons of the locus, encoding the BH3 region, were removed. Crossing with mice expressing cre in the germline removed the floxed neo cassette. mRNA was absent in mutant liver, lung, heart, and kidney. (J:104487)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bik Mutation:	11 strains or lines available

Original:	J:104487 Coultas L, et al., Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol. 2004 Feb;24(4):1570-81
All:	6 reference(s)