Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Biktm1Ast mutation
(1 available);
any
Bik mutation
(11 available)
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normal phenotype
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• homozygous mice do not display any gross malformations and have normal hematopoiesis, responses to apoptotic stimuli, and blood vessel development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Dlo mutation
(0 available);
any
Bcl2 mutation
(41 available)
Biktm1Ast mutation
(1 available);
any
Bik mutation
(11 available)
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mortality/aging
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• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age
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growth/size/body
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• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age
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• all homozygotes become runted
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immune system
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• survival of mature resting T and B cells in the absence of cytokines is impaired compared to wild-type cells and similar to mice homozygous for Bcl2tm1Dlo alone
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renal/urinary system
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• all homozygotes die from polycystic kidney disease between 2 and 4 weeks of age
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hematopoietic system
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• survival of mature resting T and B cells in the absence of cytokines is impaired compared to wild-type cells and similar to mice homozygous for Bcl2tm1Dlo alone
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growth/size/body
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• seen in about 50% of mice
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• increase in size is similar to mice homozygous for Bcl2l11tm1.1Ast alone
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reproductive system
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• variable abnormalities are seen including vacuolation, multi-nucleate syncytia, accumulation of spermatocytes, and apparent reduction in tubular cellularity, diameter, and lumen size
• the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick
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• testes weight is reduced at P21 and in adults testes weigh about 60% that of wild-type; however serum concentrations of inhibin and follicle stimulating hormone are normal
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• at P15 the number of germ cells in the testis is increased and these are mostly c-Kit+ early germ cells, but in adult males the number of germ cells is decreased by up to 10-fold compared to wild-type
• in adult males the proportion of early germ cells is increased up to 10-fold compared to controls; however the absolute number is similar to controls
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• arrest is later than in Baxtm1Sjk homozygotes as some round spermatids are present but no elongating spermatids are seen
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• males but not females are sterile
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immune system
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• increase in size is similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• in the bone marrow the pro/pre-B and immature B cell populations are reduced and the population of mature b cells is increased similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• abnormalities in T cell development in the thymus (decrease in pre-T cells and increase in pro- and mature T cells) are identical to those in mice homozygous for Bcl2l11tm1.1Ast alone
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• similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• increase in mature B cells in the spleen and bone marrow similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• increase in mature T cells in the spleen similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• survival of mature T cells is increased following cytokine withdrawal or treatment with ionomycin similar to responses in mice homozygous for Bcl2l11tm1.1Ast alone
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cellular
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• arrest is later than in Baxtm1Sjk homozygotes as some round spermatids are present but no elongating spermatids are seen
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hematopoietic system
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• increase in size is similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• in the bone marrow the pro/pre-B and immature B cell populations are reduced and the population of mature b cells is increased similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• abnormalities in T cell development in the thymus (decrease in pre-T cells and increase in pro- and mature T cells) are identical to those in mice homozygous for Bcl2l11tm1.1Ast alone
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• similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• increase in mature B cells in the spleen and bone marrow similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• increase in mature T cells in the spleen similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• similar to mice homozygous for Bcl2l11tm1.1Ast alone
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• survival of mature T cells is increased following cytokine withdrawal or treatment with ionomycin similar to responses in mice homozygous for Bcl2l11tm1.1Ast alone
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endocrine/exocrine glands
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• variable abnormalities are seen including vacuolation, multi-nucleate syncytia, accumulation of spermatocytes, and apparent reduction in tubular cellularity, diameter, and lumen size
• the spermatogonia layer is thicker than in wild-type being up to 3 cell layers thick
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• testes weight is reduced at P21 and in adults testes weigh about 60% that of wild-type; however serum concentrations of inhibin and follicle stimulating hormone are normal
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Analysis Tools
