Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tnfrsf10btm1Wsed
Name:	tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1, Wafik S El-Diery
MGI ID:	MGI:3574360
Synonyms:	DR5-
Gene:	Tnfrsf10b  Location: Chr14:70004921-70021860 bp, + strand  Genetic Position: Chr14, 36.1 cM
Alliance:	Tnfrsf10btm1Wsed page

Germline Transmission:	Earliest citation of germline transmission: J:96816
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 and 4 and part of 5 were replaced with a PGK-neo cassette in the reverse orientation, causing a downstream frame shift. The deleted sequence encompassed the extracellular domain of the gene and encoded the cystein-rich repeats. RT-PCR analysis of mutants confirmed the lack of functional gene transcription in small bowel extracts. (J:96816)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Tnfrsf10btm1Wsed

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf10b Mutation:	28 strains or lines available

Original:	J:96816 Finnberg N, et al., DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol. 2005 Mar;25(5):2000-13
All:	16 reference(s)