Phenotypes associated with this allele

• Allele Symbol: Tnfrsf10b^tm1Wsed
• Allele Name: targeted mutation 1, Wafik S El-Diery
• Allele ID: MGI:3574360
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf10b^tm1Wsed/Tnfrsf10b^tm1Wsed	involves: 129P2/OlaHsd	MGI:3574988

Genotype
MGI:3574988

hm1

• Allelic Composition: Tnfrsf10b^tm1Wsed/Tnfrsf10b^tm1Wsed
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to gamma-irradiation ( J:96816 )

• after exposure to 5 Gy, decreased apoptosis is seen in the thymus, white pulp if the spleen, liver, Peyer's patches of the ileum, and white matter of the brain; however apoptosis was similar to wild-type in the stomach, proximal colon, kidney, lung, and esophagus

• injection of TNFSF10 in combination with radiation exposure increased apoptosis in the white pulp of the spleen in wild-type mice but not in homozygous mutants

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:96816 )

• dexamethasone-induced apoptosis is decreased in the thymus, but not in the spleen

immune system

enlarged thymus ( J:96816 )

hematopoietic system

enlarged thymus ( J:96816 )

endocrine/exocrine glands

enlarged thymus ( J:96816 )