Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cpetm1Yplo
Name:	carboxypeptidase E; targeted mutation 1, Y Peng Loh
MGI ID:	MGI:3527901
Synonyms:	CPE KO
Gene:	Cpe  Location: Chr8:65045576-65146088 bp, - strand  Genetic Position: Chr8, 32.3 cM
Alliance:	Cpetm1Yplo page

Germline Transmission:	Earliest citation of germline transmission: J:95741
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 4 and 5 were deleted via Cre-mediated excision. Western blot of pituitary from mutants confirmed the lack of protein. (J:95741)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpe Mutation:	26 strains or lines available

Original:	J:95741 Cawley NX, et al., The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology. 2004 Dec;145(12):5807-19
All:	8 reference(s)