Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abi2tm1Pen
Name:	abl interactor 2; targeted mutation 1, Ann Marie Pendergast
MGI ID:	MGI:3526871
Synonyms:	Abi2-
Gene:	Abi2  Location: Chr1:60448778-60520317 bp, + strand  Genetic Position: Chr1, 30.47 cM
Alliance:	Abi2tm1Pen page

Germline Transmission:	Earliest citation of germline transmission: J:95254
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 2 and 3 with a PGK-neo. Immunoblot of MEFs or brains from mutants demonstrated a lack of protein. (J:95254)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abi2 Mutation:	40 strains or lines available

Original:	J:95254 Grove M, et al., ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol. 2004 Dec;24(24):10905-22
All:	3 reference(s)