Analysis Tools
behavior/neurological
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• after passive avoidance training mutants have significantly shorter latencies to cross into the darkened chamber and after retraining substantially more mutants pass into the darkened chamber, 75% compared to 25% of wild-type mice
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vision/eye
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• at P1 the lens is grossly distorted and the posterior region is broken open due to the absence of the posterior suture
• adult mutants have small round lenses that appear to have reformed
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• the lens capsule is thicker than normal
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• the anterior and posterior sutures fail to form
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• secondary lens fibers do not orient or migrate properly failing to make a 90 degree turn resulting in a convex rather than concave orientation in the equatorial region of the lens
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• all adult mutants have small eyes, however eyes are normal sized at E16.5 and P1 and rudimentary visual responses are intact
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nervous system
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• cortical cells are abnormally located in the corpus callosum
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• the density of apical dendritic branches is decreased in the CA1 region
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• granule cells in the dentate gyrus are less densely packed and sometimes displaced
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• the pyramidal layer is periodically interrupted by gaps
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• invaginations of layer I of the motor cortex with adjacent abnormally oriented pyramidal cells and localized heterotropic collections of disorganized neurons are seen
• regions of decreased cellularity surronded by misoriented neurons are seen in deeper layers of the motor and visual cortexes
• invaginations of layer I of the cingulate cortex were also seen in 7 out of 10 mutants
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• the overall density of spines on basal dendrites of layer III pyramidal neurons is normal but the relative proportion of spines with mushroom-type morphology is decreased and the proportion of stubby spines is increased
• the density of spines is decreased on apical dendritic branches of layer V pyramidal cells
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