Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Igf2tm3Wrk
Name:	insulin-like growth factor 2; targeted mutation 3, Wolf Reik
MGI ID:	MGI:3521799
Synonyms:	deltaDMR2, Igf2tm3Wrk-mat, Igf2tm3Wrk-pat
Gene:	Igf2  Location: Chr7:142204503-142220553 bp, - strand  Genetic Position: Chr7, 87.99 cM
Alliance:	Igf2tm3Wrk page

Germline Transmission:	Earliest citation of germline transmission: J:94521
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 54 bp core region of DMR2 (CpG18-CpG25), in exon 6, was deleted in frame following the insertion and subsequent Cre-mediated deletion of a floxed neo. This sequence encodes the E peptide or C-terminal propeptide domain of prepro-Igf2. (J:94521)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:	25 strains or lines available

Original:	J:94521 Murrell A, et al., An intragenic methylated region in the imprinted Igf2 gene augments transcription. EMBO Rep. 2001 Dec;2(12):1101-6
All:	3 reference(s)