Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Matn2tm1Asz
Name:	matrilin 2; targeted mutation 1, Atilla Aszodi
MGI ID:	MGI:3050541
Synonyms:	Matn2-
Gene:	Matn2  Location: Chr15:34306827-34436388 bp, + strand  Genetic Position: Chr15, 13.98 cM, cytoband B3.3
Alliance:	Matn2tm1Asz page

Germline Transmission:	Earliest citation of germline transmission: J:91587
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-lacZ-neo cassette replaced exon 2b, which encodes the translation start site, the signal peptide and a positively charged region of the protein. Southern blot confirmed recombination and Northern blot indicated absence of transcript in mutant MEFs. (J:91587)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Matn2 Mutation:	54 strains or lines available

Original:	J:91587 Mates L, et al., Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Matrix Biol. 2004 Jun;23(3):195-204
All:	7 reference(s)