Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rps12-ps1/Xisttm1Nbd
Name:	inactive X specific transcripts; targeted mutation 1, Neil Brockdorff
MGI ID:	MGI:3047791
Synonyms:	DeltaCJ+neo
Gene:	Xist  Location: ChrX:102503979-102526839 bp, - strand  Genetic Position: ChrX, 46.15 cM, cytoband D
Alliance:	Rps12-ps1/Xisttm1Nbd page

Germline Transmission:	Earliest citation of germline transmission: J:85305
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: A 2.5 kb sequence was deleted between 5.5 and 8 kb upstream of Xist, including Rps12-ps1 and spanning a site thought to include an upstream promoter for Xist. A floxed PGK-neo was also inserted. RT-PCR showed presence of antisense transcription upstream of Xist in mutants where none is present in wild-type. (J:85305)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xist Mutation:	8 strains or lines available

Original:	J:85305 Nesterova TB, et al., Skewing X chromosome choice by modulating sense transcription across the Xist locus. Genes Dev. 2003 Sep 1;17(17):2177-90
All:	1 reference(s)