Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Xisttm3.1Nbd
Name:	inactive X specific transcripts; targeted mutation 3.1, Neil Brockdorff
MGI ID:	MGI:3047789
Synonyms:	SPAdeltaneo
Gene:	Xist  Location: ChrX:102503979-102526839 bp, - strand  Genetic Position: ChrX, 46.15 cM, cytoband D
Alliance:	Xisttm3.1Nbd page

Germline Transmission:	Earliest citation of germline transmission: J:85305
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: In vitro cre expression excised the floxed PGK-neomycin resistance gene in Xisttm3Nbd, leaving the transcriptional terminator site, SPA-MAZ4 in the region 1.1 kb upstream of the P1 start site. RT-PCR indicates presence of ectopic sense transcription upstream of Xist in mutants. (J:85305)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xist Mutation:	8 strains or lines available

Original:	J:85305 Nesterova TB, et al., Skewing X chromosome choice by modulating sense transcription across the Xist locus. Genes Dev. 2003 Sep 1;17(17):2177-90
All:	1 reference(s)