Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xisttm3Nbd
Name:	inactive X specific transcripts; targeted mutation 3, Neil Brockdorff
MGI ID:	MGI:3047786
Synonyms:	SPA+neo
Gene:	Xist  Location: ChrX:102503979-102526839 bp, - strand  Genetic Position: ChrX, 46.15 cM, cytoband D
Alliance:	Xisttm3Nbd page

Germline Transmission:	Earliest citation of germline transmission: J:85305
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An insertion of the transcriptional terminator site, SPA-MAZ4 into the region 1.1 kb upstream of the P1 start site. Also, a floxed neomycin resistance gene was inserted. The insertion was designed to disrupt any transcription between the promoter and upstream regions. RT-PCR indicates presence of ectopic sense transcription upstream of Xist in mutants. (J:85305)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xist Mutation:	8 strains or lines available

Original:	J:85305 Nesterova TB, et al., Skewing X chromosome choice by modulating sense transcription across the Xist locus. Genes Dev. 2003 Sep 1;17(17):2177-90
All:	1 reference(s)