Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptgestm1Lpa
Name:	prostaglandin E synthase; targeted mutation 1, Laurent P Audoly
MGI ID:	MGI:3045658
Synonyms:	mPGES-1-, MPGES1-
Gene:	Ptges  Location: Chr2:30779483-30793309 bp, - strand  Genetic Position: Chr2, 21.75 cM
Alliance:	Ptgestm1Lpa page

Germline Transmission:	Earliest citation of germline transmission: J:90980
Parent Cell Line:	DBA-252 (ES Cell)
Strain of Origin:	DBA/1LacJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo was inserted to replace part of exon 1 and all of exon 2, corresponding to base pairs 35-256 of the cDNA sequence. Western blot indicated absence of protein in mutant macrophages. (J:90980)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptges Mutation:	47 strains or lines available

Original:	J:90980 Trebino CE, et al., Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9044-9
All:	52 reference(s)