Phenotypes associated with this allele

• Allele Symbol: Ptges^tm1Lpa
• Allele Name: targeted mutation 1, Laurent P Audoly
• Allele ID: MGI:3045658
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptges^tm1Lpa/Ptges^tm1Lpa	DBA/1LacJ-Ptges^tm1Lpa	MGI:3045812

Genotype
MGI:3045812

hm1

• Allelic Composition: Ptges^tm1Lpa/Ptges^tm1Lpa
• Genetic Background: DBA/1LacJ-Ptges^tm1Lpa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal pain threshold ( J:89960 )

• the inflammatory pain response is decreased in mutants and is similar to wild-type mice treated with an NSAID

immune system

decreased inflammatory response ( J:89960 , J:90980 )

• mutants have a smaller increase in prostaglandin E₂ production following treatment with arachidonic acid compared to wild-type mice (J:89960)

• mutants do not have increased prostaglandin E₂ production following treatment with lipopolysaccharide (J:89960)

• following antigen injection mutants do not develop edema and have fewer white blood cells infiltrating the injection site (J:89960)

• following immunization with chicken type II collagen mutants display a significant reduction in the severity and incidence of arthritis compared to wild-type mice (J:89960)

• 1.5 to 6 hours after lipopolysaccharide injection mutants do not display an increase in core body temperature unlike wild-type mice (J:90980)

homeostasis/metabolism

decreased prostaglandin level ( J:106147 )

• prostaglandin E2 levels are significantly reduced in null mice compared to wild-type