Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nrxn2tm1Sud
Name:	neurexin II; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:3042719
Gene:	Nrxn2  Location: Chr19:6468786-6583247 bp, + strand  Genetic Position: Chr19, 4.65 cM
Alliance:	Nrxn2tm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:89452
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Immunoblotting of mutant brain confirmed lack of protein expression. This knock-out affects the alpha isoform specifically. The beta isoform, transcribed from a downstream promoter, is not affected.. (J:89452)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nrxn2 Mutation:	87 strains or lines available

Original:	J:89452 Missler M, et al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003 Jun 26;423(6943):939-48
All:	12 reference(s)