Ighmtm1Fbb
Targeted Allele Detail
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| Symbol: |
Ighmtm1Fbb |
| Name: |
immunoglobulin heavy constant mu; targeted mutation 1, Frank Brombacher |
| MGI ID: |
MGI:3037070 |
| Synonyms: |
IgM- |
| Gene: |
Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
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| Alliance: |
Ighmtm1Fbb page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:57600
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| Parent Cell Line: |
BALB/c-I (ES Cell)
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| Strain of Origin: |
BALB/cJ
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intergenic deletion
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Mutation details: A single loxP site remained in place of a genomic fragment encompassing Igh-6 exons mu1 through mu4 and a portion of the intergenic region between Igh-6 and Igh-5 after the incorporation and subsequent excision of a floxed neo-HSV cassette. The intergenic region contained regulatory cis-elements of the Igh-5 locus. IgM (Igh-6) was undetected by flow cytometric analysis whereas levels of soluble IgD (Igh-5) were increased relative to wild-type.
(J:57600)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ighm Mutation: |
55 strains or lines available
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| Original: |
J:57600 Lutz C, et al., IgD can largely substitute for loss of IgM function in B cells. Nature. 1998 Jun 25;393(6687):797-801 |
| All: |
15 reference(s) |
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Analysis Tools
