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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighmtm1Fbb
targeted mutation 1, Frank Brombacher
MGI:3037070
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighmtm1Fbb/Ighmtm1Fbb involves: BALB/cJ MGI:3037082


Genotype
MGI:3037082
hm1
Allelic
Composition		 Ighmtm1Fbb/Ighmtm1Fbb
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Fbb mutation (0 available); any Ighm mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:57600 )
N
• normal B cell development and maturation, the expression of IgD (Igh-5) largely compensates for the lack of IgM (Igh-6)
increased susceptibility to Riboviria infection ( J:57600 )
• while mice survived infection with vesicular stomatitis virus by developing neutralizing immunoglobulins, the immune response was delayed relative to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory