Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sema4dtm1Kik
Name:	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; targeted mutation 1, Hitoshi Kikutani
MGI ID:	MGI:3027762
Synonyms:	CD100-, Sema4D(-)
Gene:	Sema4d  Location: Chr13:51839565-51947783 bp, - strand  Genetic Position: Chr13, 26.16 cM, cytoband B1
Alliance:	Sema4dtm1Kik page

Germline Transmission:	Earliest citation of germline transmission: J:66033
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The putative exon 1 which contains the initiation codon was replaced with a neomycin resistance cassette. Absence of expression was established by immunological staining of spleen cells. (J:66033)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sema4d Mutation:	87 strains or lines available

Original:	J:66033 Shi W, et al., The class IV semaphorin CD100 plays nonredundant roles in the immune system. Defective B and T cell activation in CD100-deficient mice. Immunity. 2000 Nov;13(5):633-42
All:	22 reference(s)