Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ubr2tm1Ytkw Name: ubiquitin protein ligase E3 component n-recognin 2; targeted mutation 1, Yong Tae Kwon MGI ID: MGI:2682037 Synonyms: UBR2- Gene: Ubr2  Location: Chr17:47239221-47321482 bp, - strand  Genetic Position: Chr17, 22.91 cM Alliance: Ubr2tm1Ytkw page

Abnormal development of the central nervous system in Ubr1tm1Avar/Ubr1tm1Avar Ubr2tm1Ytkw/Ubr2tm1Ytkw embryos Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:86438
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: DNA from codon 7 (Cys) of exon 3 through codon 16 (His) of exon 6 was replaced in frame with the nuclear localization signal(NLS)-lacZ marker gene. No beta-galactosidase activity was observed however. Low levels of gene transcript could be detected by Northern blot. (J:86438)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubr2 Mutation:	86 strains or lines available

Original:	J:86438 Kwon YT, et al., Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol. 2003 Nov;23(22):8255-71
All:	6 reference(s)