Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nod2tm1Pmu
Name:	nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Peter J Murray
MGI ID:	MGI:2680581
Synonyms:	Card15-, Nod2-
Gene:	Nod2  Location: Chr8:89373943-89415102 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Alliance:	Nod2tm1Pmu page

Germline Transmission:	Earliest citation of germline transmission: J:86264
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The start codon, first CARD domain and half of the second CARD domain were eliminated by replacing the first exon with a PGK-neomycin resistance gene. RT-PCR on macrophage extracts demonstrated the absence of gene transcript. (J:86264)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

10 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:	62 strains or lines available

Original:	J:86264 Pauleau AL, et al., Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol. 2003 Nov;23(21):7531-9
All:	13 reference(s)