Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pigrtm1Rast
Name:	polymeric immunoglobulin receptor; targeted mutation 1, Richard A Strugnell
MGI ID:	MGI:2651659
Synonyms:	pIgR-
Gene:	Pigr  Location: Chr1:130754421-130779986 bp, + strand  Genetic Position: Chr1, 56.89 cM, cytoband E3
Alliance:	Pigrtm1Rast page

Germline Transmission:	Earliest citation of germline transmission: J:81984
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The targeting vector used to generate Pigrtm1Fejo was electroporated into ES cells derived from a C57BL/6 genetic background. Exon 3, which encodes the ligand binding extracellular receptor domain 1 (D1), was disrupted by a neomycin selection cassette inserted by homologous recombination. (J:81984)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Pigr Mutation:	59 strains or lines available

Original:	J:81984 Uren TK, et al., Role of the polymeric Ig receptor in mucosal B cell homeostasis. J Immunol. 2003 Mar 1;170(5):2531-9
All:	9 reference(s)