Adipoqtm1Ish
Targeted Allele Detail
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Symbol: |
Adipoqtm1Ish |
Name: |
adiponectin, C1Q and collagen domain containing; targeted mutation 1, Iichiro Shimomura |
MGI ID: |
MGI:2387344 |
Synonyms: |
Adipo-, APN-KO |
Gene: |
Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
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Alliance: |
Adipoqtm1Ish page
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Germline Transmission: |
Earliest citation of germline transmission:
J:77479
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Parent Cell Line: |
AB2.2 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Parts of introns 1 and 2, and regions of exon 2, which contains the translation initiation sites, were replaced by a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in plasma of homozygous mutants.
(J:77479)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Adipoq Mutation: |
40 strains or lines available
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Original: |
J:77479 Maeda N, et al., Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002 Jul;8(7):731-7 |
All: |
82 reference(s) |
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