Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igf1rtm1Mhz
Name:	insulin-like growth factor I receptor; targeted mutation 1, Martin Holzenberger
MGI ID:	MGI:2386327
Synonyms:	IGF-IRneo
Gene:	Igf1r  Location: Chr7:67602575-67883416 bp, + strand  Genetic Position: Chr7, 37.27 cM
Alliance:	Igf1rtm1Mhz page

Germline Transmission:	Earliest citation of germline transmission: J:63460
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 3 was flanked by a floxed neo cassette inserted into intron 2 and a single loxP site in intron 3. Several aberrant transcripts involving the splicing of exon 2 to cryptic slice sites in the neo transgene were identified by RT-PCR and sequence analyses. Further analysis indicated that the readthrough of the neo transgene will result in functional ablation due to truncation or the inclusion of a random neo fragment. Mice carrying this allele were crossed with transgenic mice expressing cre recombinase via the EIIa promoter to generate Igf1rtm1.1Mhz and Igf1rtm1.2Mhz. (J:63460)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:	86 strains or lines available

Original:	J:63460 Holzenberger M, et al., A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology. 2000 Jul;141(7):2557-66
All:	5 reference(s)