Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gdf15tm1Sjl
Name:	growth differentiation factor 15; targeted mutation 1, Se-Jin Lee
MGI ID:	MGI:2386300
Gene:	Gdf15  Location: Chr8:71082043-71085106 bp, - strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Alliance:	Gdf15tm1Sjl page

Germline Transmission:	Earliest citation of germline transmission: J:61788
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette via homologous recombination. Exon 2 encodes the entire C-terminal domain of the protein. Homozygous mutant animals lack gene expression as demonstrated by Northern blot analysis of liver RNA using a probe to the C-terminal region of the gene. (J:61788)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf15 Mutation:	26 strains or lines available

Original:	J:61788 Hsiao EC, et al., Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 2000 May;20(10):3742-51
All:	35 reference(s)