Phenotypes associated with this allele

• Allele Symbol: Gdf15^tm1Sjl
• Allele Name: targeted mutation 1, Se-Jin Lee
• Allele ID: MGI:2386300
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf15^tm1Sjl/Gdf15^tm1Sjl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3640486
cx2	Gdf15^tm1Sjl/Gdf15^tm1Sjl Lepr^db/Lepr^db	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J	MGI:5548175

Genotype
MGI:3640486

hm1

• Allelic Composition: Gdf15^tm1Sjl/Gdf15^tm1Sjl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial infarct size ( J:118878 )

• mice subjected to transient coronary artery ligation for 1 hour followed by reperfusion for 24 hours develop greater myocardial infarct sizes and show more cardiomyocyte apoptosis in the infarct border zone compared to wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:61788 )

N • no obvious phenotypic abnormalities are detected and response to liver injury and liver regeneration after injury are both normal

increased myocardial infarct size ( J:118878 )

• mice subjected to transient coronary artery ligation for 1 hour followed by reperfusion for 24 hours develop greater myocardial infarct sizes and show more cardiomyocyte apoptosis in the infarct border zone compared to wild-type mice

increased platelet aggregation ( J:195443 )

• platelet-rich plasma shows slightly increased platelet aggregation after stimulation with platelet agonists, ADP or U46619

increased susceptibility to induced thrombosis ( J:195443 )

• mice show accelerated thrombus formation after collagen-induced pulmonary thromboembolism

• mice exhibit accelerated time to thrombus formation and vessel occlusion after ferric chloride-injduced injury of the mesenteric artery

decreased bleeding time ( J:195443 )

increased urine glucose level ( J:202996 )

• urinary glucose excretion is higher in STZ-induced diabetic mutants than in diabetic wild-type mice

hematopoietic system

increased platelet aggregation ( J:195443 )

• platelet-rich plasma shows slightly increased platelet aggregation after stimulation with platelet agonists, ADP or U46619

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:195443 )

• mice show reduced survival rate compared to wild-type mice after collagen-induced pulmonary thromboembolism

behavior/neurological

increased fluid intake ( J:202996 )

• water intake and urine output in mutants with STZ-induced diabetes is increased at day 7 and 14 compared to wild-type diabetic mutants that show an increase at day 7 which then returns to normal levels at day 14

increased food intake ( J:202996 )

• mice show increased food intake following STZ-induced diabetes compared to nondiabetic mutants or diabetic wild-type mice

growth/size/body

decreased body weight ( J:202996 )

increased kidney weight ( J:202996 )

• increase in kidney weight and kidney-to-body weight ratio

renal/urinary system

increased urine glucose level ( J:202996 )

• urinary glucose excretion is higher in STZ-induced diabetic mutants than in diabetic wild-type mice

abnormal kidney morphology ( J:202996 )

• marker analysis of STZ-induced diabetic mutants shows increased renal damage compared to diabetic wild-type mice, despite similar blood glucose levels

increased kidney weight ( J:202996 )

• increase in kidney weight and kidney-to-body weight ratio

polyuria ( J:202996 )

• water intake and urine output in mutants with STZ-induced diabetes is increased at day 7 and 14 compared to wild-type diabetic mutants that show an increase at day 7 which then returns to normal levels at day 14

Genotype
MGI:5548175

cx2

• Allelic Composition: Gdf15^tm1Sjl/Gdf15^tm1Sjl; Lepr^db/Lepr^db
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

behavior/neurological

increased fluid intake ( J:202996 )

♂ • water intake and urine output are increased at week 9 compared to single Lepr mutants

increased food intake ( J:202996 )

♂ • food intake is increased over single Gdf15 mutants but is similar to single Lepr mutants

cardiovascular system

increased heart weight ( J:202996 )

♂ • increase in heart weight compared to controls, including that in single Lepr mutants

growth/size/body

increased heart weight ( J:202996 )

♂ • increase in heart weight compared to controls, including that in single Lepr mutants

increased body weight ( J:202996 )

♂ • body weight is increased over nondiabetic single Gdf15 mutants but is similar to single Lepr mutants

increased kidney weight ( J:202996 )

♂ • kidney weight is increased to a similar extent as in single Lepr mutants

increased liver weight ( J:202996 )

♂ • liver weight is increased to a similar extent as in single Lepr mutants

homeostasis/metabolism

increased circulating creatinine level ( J:202996 )

♂ • increase in serum creatinine levels compared to controls, including that in single Lepr mutants

hyperglycemia ( J:202996 )

♂ • nonfasting blood glucose and HbA1c are higher in double mutants than in single Lepr mutants at the final time point of 18 weeks but are similar at earlier time points but higher than in single Gdf15 mutants

increased urine glucose level ( J:202996 )

♂ • urinary glucose loss is higher than in single Lepr mutants at week 14

increased cholesterol level ( J:202996 )

♂ • similar increase in cholesterol level as in single Lepr mutants

increased circulating HDL cholesterol level ( J:202996 )

♂ • similar increase in HDL levels as in single Lepr mutants

albuminuria ( J:202996 )

♂ • similar increase in urinary albumin excretion as in single Lepr mutants

liver/biliary system

increased liver weight ( J:202996 )

♂ • liver weight is increased to a similar extent as in single Lepr mutants

renal/urinary system

increased urine glucose level ( J:202996 )

♂ • urinary glucose loss is higher than in single Lepr mutants at week 14

albuminuria ( J:202996 )

♂ • similar increase in urinary albumin excretion as in single Lepr mutants

abnormal kidney morphology ( J:202996 )

♂ • marker analysis indicates that double mutants show an increase in renal damage and in interstitial and tubular damage in the kidney compared to single Lepr mutants

increased kidney weight ( J:202996 )

♂ • kidney weight is increased to a similar extent as in single Lepr mutants

glomerulosclerosis ( J:202996 )

♂ • glomerulosclerosis is similar as in single Lepr mutants

polyuria ( J:202996 )

♂ • water intake and urine output are increased at week 9 compared to single Lepr mutants