Hsd11b1tm1Yko
Targeted Allele Detail
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Symbol: |
Hsd11b1tm1Yko |
Name: |
hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Yuri V Kotelevtsev |
MGI ID: |
MGI:2385796 |
Synonyms: |
11beta-HSD-1-, 11beta-HSD1-, HSD1- |
Gene: |
Hsd11b1 Location: Chr1:192903948-192946353 bp, - strand Genetic Position: Chr1, 97.67 cM
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Alliance: |
Hsd11b1tm1Yko page
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Hsd11b1tm1Yko/Hsd11b1tm1Ykomice show lipid accumulation in the liver
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:37960
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Parent Cell Line: |
CGR8 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette containing a human beta actin promoter replaced a genomic sequence encompassing exons 3 and 4. Northern blot analyses of liver and brain did not detect mRNA in homozygous mutant mice. Enzyme function analyses of tissues from homozygous mutant mice detected less than 5% of wild-type enzyme levels in liver and did not detect enzyme in brain.
(J:45085)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hsd11b1 Mutation: |
27 strains or lines available
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Original: |
J:37960 Kotelevtsev YV, et al., Inactivation of 11 beta-hydroxysteroid dehydrogenase type 1 by gene targeting in mice. Endocr Res. 1996;22(4):791-792 |
All: |
33 reference(s) |
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